Peg3 imprinted gene on proximal chromosome 7 encodes for a zinc finger protein.

摘要

Genetic and embryological studies in the mouse demonstrated functional difference between parental chromosomes during development (Surani, M.A.H. et al. 1984, McGrath, J. & Solter, D. 1984). This is due to imprinted genes whose expression is dependenton their parental origin. In our attempt to screen imprinted genes systematically, we have developed a subtraction hybridization methods and have identified 8 paternally expressed genes ,Pegl-8 (Kaneko-Ishino, T. et al. 1985 and in press, Kuroiwa, Y. etd. 1996, Kagitani, F. et al. submitted). The third imprinted genes in our screening named Peg3 (paterndly expressed gene 3) was mapped on proximal chromosome 7 and it is the first imprinted gene identified on this region (Kuroiwa, Y. et al. 1996). It has been demonstrated that maternal disomy of this region causes a neonatal lethality (Searle, A.G. & Beechey, C. V. 1990, Cattanach, B.M. et al. 1992).