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Transcribing neonatal diabetes mellitus.

机译:抄录新生儿糖尿病。

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摘要

A recent study by Smith and colleagues1 shows that the transcription factor Rfx6 is mandatory for the development of pancreatic endocrine cells. These investigators carried out experiments in a mouse model and in human tissue specimens and obtained highly concordant results (Fig. 1). They showed that, in mice, Rfx6 is expressed in the definitive endoderm early during development and is then restricted to the gut and pancreatic bud, reactivated in endocrine progenitors, and ultimately restricted to pancreatic islets in adults. They also found that RFX6 is expressed in human pancreatic tissue with an expression pattern consistent with that of Rfx6 in adult mice. Rfx6-deficient mice exhibited gross bowel distention due to small-bowel obstruction and died within 2 days post partum. Although the pancreas was present, with many endocrine cells positive for chromo-granin, these cells did not express the hormones insulin, glucagon, somatostatin, or ghrelin.
机译:Smith及其同事最近的一项研究显示,转录因子Rfx6是胰腺内分泌细胞发育所必需的。这些研究人员在小鼠模型和人体组织样本中进行了实验,并获得了高度一致的结果(图1)。他们表明,在小鼠中,Rfx6在发育早期在定形内胚层中表达,然后局限于肠道和胰芽,在内分泌祖细胞中重新激活,并最终限于成年胰岛。他们还发现,RFX6在人胰腺组织中表达的表达模式与成年小鼠中Rfx6一致。缺乏Rfx6的小鼠由于小肠阻塞而表现出大肠扩张,并在产后2天内死亡。尽管存在胰腺,但许多内分泌细胞对嗜铬粒蛋白呈阳性,但这些细胞不表达胰岛素,胰高血糖素,生长抑素或生长素释放肽等激素。

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