Cyclic Nucleotide Second Messengers (cAMP and cGMP) Play a Central Role in Signal Transduction and Regulation of Mesenteric Postcapillary Fluid Leak

摘要

In severely injured or septic patients, various inflammatory mediators are released that impact microvascular fluid permeability. Previous work from our laboratory has centered on the endothelial-derived mediators endothelin-1 (ET-1), angiotensin II (Ang II), and platelet-activating factor (PAF).1'2 ET-1 decreases fluid leak from postcapillary venules, while PAF and Ang II increase fluid leak.3~5 Despite studies on the effects of these factors, the intracellular mechanisms involved with changes in microvascular fluid permeability have not been elucidated.