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首页> 外文期刊>The Journal of Thoracic and Cardiovascular Surgery >Effect of acutely increased left ventricular afterload on work output from the right ventricle in conscious dogs.
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Effect of acutely increased left ventricular afterload on work output from the right ventricle in conscious dogs.

机译:在有意识的狗中,左心室后负荷急剧增加对右心室工作输出的影响。

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摘要

OBJECTIVE: To determine the effect of acute increments in left ventricular afterload on the stroke work output of the right ventricle in vivo. METHODS: After pharmacologic attenuation of autonomic reflexes, left and right ventricular pressure-volume data were obtained in 9 conscious dogs during vena caval occlusions performed before and during aortic constriction. RESULTS: The relationship between right ventricular stroke work and end-diastolic volume during vena caval occlusion was highly linear (r = 0.97 +/- 0.02), but the slope decreased by 20% +/- 13% during aortic constriction sufficient to increase left ventricular mean ejection pressure by 25% +/- 14% (P <.05). The volume-axis intercept remained constant. Similarly, the slope of the linear relationship between right ventricular free wall regional segment work and end-diastolic segment length declined by 22% +/- 10% during aortic constriction (P <.05), without significant change in the length-axis intercept. The reduction in both global and regional right ventricular stroke work at any given preload with increased left ventricular afterload was due entirely to decreased right ventricular stroke volume and free wall shortening, because right ventricular mean ejection pressure was unchanged. Additional experiments were performed in 5 open-chest dogs to produce a greater reduction in left ventricular free wall shortening than observed with aortic constriction by transient constriction of the left circumflex coronary artery. However, this intervention had no effect on right ventricular free wall segment work output. CONCLUSION: Increased left ventricular afterload decreases global and regional right ventricular stroke work at any given preload, a direct, negative systolic ventricular interaction.
机译:目的:确定左心室后负荷急性增加对体内右心室中风功输出的影响。方法:在药理学上减轻自主神经反射后,在主动脉狭窄之前和期间进行腔静脉阻塞的9只清醒犬中获得了左右心室压力数据。结果:腔静脉阻塞期间右心室搏动功与舒张末期容积之间的关系呈高度线性关系(r = 0.97 +/- 0.02),但在主动脉缩窄期间斜率下降了20%+/- 13%,足以增加左心室心室平均射血压力降低25%+/- 14%(P <.05)。体积轴截距保持恒定。同样,在主动脉缩窄期间,右心室自由壁区域段工作与舒张末期段长度之间的线性关系的斜率下降了22%+/- 10%(P <.05),而长度轴截距没有明显变化。在任何给定的预紧力下,随着左心室后负荷的增加,整体和局部右心室卒中工作的减少完全是由于右心室搏动量减少和自由壁缩短所致,因为右心室平均射血压力没有改变。在5只开胸的狗中进行了另外的实验,以产生比通过左旋支冠状动脉的短暂收缩引起的主动脉收缩所观察到的更大的左心室游离壁缩短。但是,这种干预对右心室自由壁节段的工作输出没有影响。结论:在任何给定的预紧力下,左心室后负荷增加会降低整体和区域性右心室中风功,这是直接的,负性收缩期心室相互作用。

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