A Short, Efficient, and Stereoselective Total Synthesis of a Pyrrolidine Alkaloid: (-)-Codonopsinine

摘要

An efficient total synthesis of antibiotic (-)-codonopsinine 1 with an overall yield of 44% was achieved from D-alanine as a chiral template. The key steps in our strategy are modified Sharpless asymmetric dihydroxylation reaction and the highly Stereoselective intramolecular acid-catalyzed ami-docyclization.