Practical and highly stereoselective approaches to the total synthesis of (-)-codonopsinine

摘要

The enantiopure total synthesis of (-)-codonopsinine is described using two effective chiron approaches starting either from commercially available L-xylose or from readily available Garner aldehyde. The key steps included Julia trans-olefination, highly diastereoselective alkylation and cascade epoxidation-cyclization strategies. (c) 2006 Elsevier Ltd. All rights reserved.