首页> 外文期刊>The Journal of hospital infection >World Health Organization-recommended hand-rub formulations do not meet European efficacy requirements for surgical hand disinfection in five minutes.
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World Health Organization-recommended hand-rub formulations do not meet European efficacy requirements for surgical hand disinfection in five minutes.

机译:世界卫生组织推荐的手揉搓配方在五分钟内不符合欧洲手术手消毒的功效要求。

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摘要

The World Health Organization (WHO) has recommended two hand-rub formulations for local production based on 80% ethanol or 75% isopropanol (both v/v). We have looked at their efficacy according to EN 12791. Twenty-six subjects treated their hands with the reference procedure (n-propanol, 60%) for 3 min or with one of the two formulations for 1.5, 3 or 5 min (Latin square design). Post-values (immediate effect) were taken from one hand, the other hand was gloved for 3 h. After the glove had been taken off, the second post-value was taken (3 h effect). The mean log(10) reduction of each hand rub at all three application times was compared to Hodges and Lehmann's reference procedure for non-inferiority. In the first block the reference procedure reduced bacterial load by 2.43 log(10) (immediate effect) and 2.22 log(10) (3 h effect). The efficacy of the ethanol-based formulation (e.g. immediate efficacy of 1.41 log(10) at 5 min) was inferior to the reference procedure at all application times [lower 95% confidence interval (CI): less than -0.75]. In the second block the reference procedure reduced bacterial load by 2.72 log(10) (immediate effect) and 2.26 log(10) (3 h effect). The efficacy of the isopropanol-based formulation (e.g. immediate efficacy of 2.05 log(10) at 5 min) was also inferior to the reference procedure at all application times (lower 95% CI: less than -0.75). Both WHO-recommended hand-rub formulations failed to meet the EN 12791 efficacy requirements for surgical hand disinfection within 5 min. A higher concentration of the active ingredients may improve the efficacy.
机译:世界卫生组织(WHO)已推荐两种基于80%乙醇或75%异丙醇(均为v / v)的手揉搓配方用于本地生产。我们已经根据EN 12791评估了它们的功效。26位受试者用参考程序(正丙醇,60%)处理了3分钟,或者用两种配方之一处理了1.5、3或5分钟(拉丁方)。设计)。从一只手取后值(即时效果),另一只手戴手套3小时。摘下手套后,取第二个后值(3小时效果)。将所有三个应用时间的每次擦手的平均log(10)减少量与Hodges和Lehmann的非自卑参考程序进行了比较。在第一个步骤中,参考程序将细菌载量降低了2.43 log(10)(立即作用)和2.22 log(10)(3小时作用)。在所有应用时间,基于乙醇的制剂的功效(例如5分钟的即时功效为1.41 log(10))均低于参考程序[较低的95%置信区间(CI):小于-0.75]。在第二个步骤中,参考程序将细菌负荷降低了2.72 log(10)(立即作用)和2.26 log(10)(3小时作用)。基于异丙醇的制剂的功效(例如,在5分钟时的即时功效为2.05 log(10))在所有施用时间下也均低于参考程序(较低的95%CI:小于-0.75)。两种WHO推荐的手揉搓配方均未能在5分钟内达到EN 12791的手术手消毒功效要求。较高浓度的活性成分可以改善功效。

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