Polymorphisms of the CYP2C19 gene in Japanese patients with aspirin-exacerbated respiratory disease.

摘要

Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome characterized by a severe asthma attack after taking aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), or both. Because aspirin intolerance is found in a specific population, genetic predisposition is considered a crucial determinant for its development. Candidate studies have concentrated on the leukotriene-related genes; however, conflicting results have been reported. Recently, Higashi et al demonstrated that prosta-glandin D_2 was overproduced during aspirin-intolerant broncho-constriction, and no differences in the levels of lipoxygenase products have been found in blood from patients with AERD and those with aspirin-tolerant asthma (ATA).