Asymmetric bromination-aldolization of chiral acetate titanium enolate derived from thioimide. A general approach to the synthesis of enantiopure alpha-bromo-beta-hydroxy carboxylic acids.

摘要

Chiral acetate titanium enolate derived from thioimide efficiently effects one-step bromination-aldolization with excellent yields and exceptionally high levels of asymmetric induction in aldol additions. General base promoted oxazolidinethione deacylation provides direct access to chiral alpha-bromo-beta-hydroxy acids. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 14]