A NEW METHOD FOR PREPARATION OF 3,6-DIHYDRO-2H-1,3-OXAZINES AND EXPLORATIONS OF THEIR USE IN STEREOSELECTIVE SYNTHESIS OF 1,3-AMINO ALCOHOL DERIVATIVES

摘要

Condensation of P-hydroxy aldehydes with N-sulfonyl aldimines produces 3,6-dihydro-2H-1,3-oxazines in moderate to excellent yields. The process is stereoselective, with the C-2 and C-6 substituents having a trans relationship in these heterocycles. Some transformations of these oxazines as potential acyclic 1,3-amino alcohol synthons are described. [References: 30]