Stereoselective method for producing a 1,3-amino alcohol derivative

摘要

PROBLEM TO BE SOLVED: To provide a method for highly stereoselectively producing an optically active 1,3-amino alcohol derivative with ease in a high yield by the catalytically asymmetric nucleophilic addition reaction of the aldol addition reaction type using an aldehyde compound and an enamine or its derivative.;SOLUTION: The method for producing an optically active 1,3-amino alcohol derivative having an N, O-acetal structure comprises treating a polymer formed as an intermediate with a Lewis acid such as scandium triflate in ethanol to effectively decompose the polymer in the asymmetric nucleophilic addition reaction for reacting an aldehyde with an enamine derived from an aldehyde in the presence of an asymmetric catalyst composed of a monovalent copper compound and a chiral diamine ligand. Furthermore, the method for producing the corresponding optically active 1,3-amino alcohol derivative comprises treating the above polymer with an allylating agent or a reducing agent in the presence of a Lewis acid.;COPYRIGHT: (C)2007,JPO&INPIT