Solution-Phase Ring Opening Cross-Metathesis of Bicyclic Alkenes with Styrene Derivatives and Its Application to 'Resin Capture' Solid-Phase Synthesis

摘要

The solution-phase ring opening cross-metathesis (ROM) of bicyclic alkenes with styrene derivatives is described. The influence of bicyclic alkene substituents on the rate and product distribution of solution-phase ROM reactions with styrene derivatives is discussed. In addition, a method for the "resin capture" of solution-phase ROM products by resin-bound amines is also illustrated.