Solid-Phase Synthesis of Hydrophobic Peptides on 1,6-Hexanediol Diacrylate Crosslinked Poly-Styrene Resin: Comparison with Merrifield Resin

摘要

A novel polymer support based on 1,6-hexanediol diacrylate and polystyrene was developed. The resin showed better solvation in solvents used for peptide synthesis than Merrifield resin. The synthetic utility of the new support has been illustrated with the synthesis of some hydrophobic peptides which have high affinity for aggregation. The yield and purity of the peptides were high compared to when Merrifield resin was used.