Cerebral Blood Flow Measurement without Absolute Input Function Value for PET O-15 Injection Method

摘要

This paper presents a method of regional cerebral blood flow (CBF) measurement using PET data and an input function not involving the absolute concentration value of radioactivity. The value of the input function and the output function can be obtained from clinical data by regression analysis. The input and output functions are transformed to their Fourier image functions by the Fourier transform. The transfer function of the differential equation of a compartment model is obtained from these image functions. The CBF can be estimated by transfer function regression analysis. The results of the proposed and conventional methods are compared.