Synthesis and Rearrangement of 2-(N-Methyl-N-nitroamino)-4-phenylthiazole

摘要

2-(N-Methyl-N-nitroamino)-4-phenylthiazole was prepared and rearranged in aqueous dioxane under influence of sulphuric acid of various concentrations.2-(N-Methyl-amino)-5-nitro-4-phenylthiazole was the only product up to 50% acid concentration.At higher acidities,significant amounts of nitro derivatives 3b and 3c,substituted in benzene ring,were also formed.The result indicates that migration of the N-nitro group occurs on the intramolecular path,however,in concentrated sulphuric acid,formation of nitronium ion and ring nitration also takes place.