Mutations in DCC Cause Congenital Mirror Movements

摘要

Mirror movements (MM) are contralateral involuntary movements that mirror voluntary ones. MM are occasionally found in young children, but persistence beyond age 10 is unusual except in certain disorders of nervous system crossing such as Klippel-Feil and Kallmann syndrome. The study of individuals with MM can provide important insights into the mechanisms of contralateral innervation.rnWe recently described a large four-generation French Canadian (FC) family with isolated congenital MM (CMM) (1). Pedigree analysis suggested autosomal dominant inheritance with incomplete penetrance.