Molecular links among the causative genes for ocular malformation: Otx2 and Sox2 coregulate Rax expression

摘要

The neural-related genes Sox2, Pax6. Otx2, and Rax have been associated with severe ocular malformations such as anophthalmia and microphthalmia, but it remains unclear as to how these genes are linked functionally. We analyzed the upstream signaling of X