Loss of protein kinase C inhibition in the β-T594M variant of the amiloride-sensitive Na+ channel

摘要

We previously reported the presence of a novel variant (β-T594M) of the amiloride-sensitive Na+ chan- nel (ASSC) in which the threonine residue at position 594 in the β-subunit has been replaced by a methionine residue. Electrophysiological studies of the ASSC on Epstein-Barr virus (EBV)-transformed lymphocytes carrying this variant showed that the 8-(4-chlorophenylthio) adenosine 3':5'-cyclic monophosphate (8cpt-cAMP)-induced responses were en- hanced when compared to wild-type EBV-transformed lym- phocytes.