PYRROLE 2,3-DPYRIMIDINE DERIVATIVES, A PHARMACEUTICAL COMPOSITION (VARIANTS), A METHOD FOR INHIBITION OF PROTEIN TYROSINE KINASE OR JANUS KINASE 3 OF MAMMALS (VARIANTS) AND A METHOD FOR TREATMENT (VARIANTS)

摘要

A compound of formula (I) wherein R1, R2 and R3 are as denned in the description, and are inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase (3) and as such are useful therapy as immunosuppressive agents for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis. Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases. , (?)