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A Network Model of Perceptual Suppression Induced by Transcranial Magnetic Stimulation

机译:经颅磁刺激诱导知觉抑制的网络模型

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We modeled the inhibitory effects of transcranial magnetic stimulation (TMS) on a neural population. TMS is a noninvasive technique, with high temporal resolution, that can stimulate the brain via a brief magnetic pulse from a coil placed on the scalp. Because of these advantages, TMS is extensively used as a powerful tool in experimental studies of motor, perception, and other functions in humans. However, the mechanisms by which TMS interferes with neural activities, especially in terms of theoretical aspects, are totally unknown. In this study, we focused on the temporal properties of TMS-induced perceptual suppression, and we computationally analyzed the response of a simple network model of a sensory feature detector system to a TMS-like perturbation. The perturbation caused the mean activity to transiently increase and then decrease for a long period, accompanied by a loss in the degree of activity localization. When the afferent input consisted of a dual phase, with a strong transient component and a weak sustained component, there was a critical latency period of the perturbation during which the network activity was completely suppressed and converged to the resting state. The range of the suppressive period increased with decreasing afferent input intensity and reached more than 10 times the time constant of the neuron. These results agree well with typical experimental data for occipital TMS and support the conclusion that dynamical interaction in a neural population plays an important role in TMS-induced perceptual suppression.
机译:我们模拟了经颅磁刺激(TMS)对神经群体的抑制作用。 TMS是一种具有高时间分辨率的非侵入性技术,可以通过放置在头皮上的线圈发出的短暂电磁脉冲刺激大脑。由于这些优点,TMS被广泛用作人类运动,感知和其他功能的实验研究中的强大工具。但是,TMS干扰神经活动的机制,特别是在理论方面,是完全未知的。在这项研究中,我们专注于TMS引起的知觉抑制的时间特性,并且我们通过计算分析了感官特征检测器系统的简单网络模型对类似TMS的扰动的响应。扰动导致平均活动在很长一段时间内短暂地增加然后减少,伴随着活动本地化程度的降低。当传入输入由具有强瞬态分量和弱持续分量的双相组成时,存在一个扰动的临界潜伏期,在此期间网络活动被完全抑制并收敛到静止状态。抑制期的范围随着传入输入强度的降低而增加,并达到神经元时间常数的10倍以上。这些结果与枕部TMS的典型实验数据非常吻合,并支持以下结论:神经群体中的动力相互作用在TMS诱导的知觉抑制中起重要作用。

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