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首页> 外文期刊>Materials science & engineering. C, Biomimetic materials, sensors and systems >Bone tissue engineering based on bead–cell sheets composed of calcium phosphate beads and bone marrow cells
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Bone tissue engineering based on bead–cell sheets composed of calcium phosphate beads and bone marrow cells

机译：基于由磷酸钙珠和骨髓细胞组成的珠-细胞片的骨组织工程

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摘要

We developed a new tissue-engineered bone graft model composed of bovine bone marrow stromal cells (BMSCs), and beta tricalcium phosphate (beta TCP) porous beads. Such cell–bead sheets were prepared by means of cultivation of BMSCs with the beads in alpha-MEM culture medium supplemented with 10% fetal bovine serum. The shape of the sheets was possible to change depending on that of a plastic mold having a circle or quadrangle shape. Addition of poundage on the overlaid cell–bead sheets induced the connection of these sheets with each other, and achievement of thicker implant formation. A nonwoven fabric sheet of poly-L-lactic acid (PLLA) could also be inserted in between each cell–bead sheet. Consequently, bone implants having a size of 20 *20 * 5 mm were successfully developed. This kind of techniques would be useful in thick implants for other tissue implants.
机译：我们开发了一种新的组织工程化的骨移植模型，该模型由牛骨髓基质细胞（BMSC）和β-磷酸三钙（βTCP）多孔珠组成。通过在含有10％胎牛血清的alpha-MEM培养基中用BMSC培养BMSCs来制备这种细胞珠片。片的形状可以根据具有圆形或四边形形状的塑料模具的形状而改变。在覆盖的细胞珠片上增加磅数会导致这些片之间相互连接，并实现更厚的植入物形成。也可以在每个细胞珠片之间插入一个聚L-乳酸（PLLA）的无纺布片。因此，成功开发了尺寸为20 * 20 * 5 mm的骨植入物。这种技术对于其他组织植入物的厚植入物很有用。

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  • 作者

    Katsuko S. Furukawa; Shunsuke Miyauchi; Daisuke Suzuki; Yoshikazu Umezu; Tsuneo Shinjo; Takashi Ushida; Miki Eguchi; Tetsuya Tateishi;

  • 作者单位

    Biomedical Engineering (Ushida and Furukawa), Laboratory, Department of Mechanical Engineering, Graduate School of Engineering, University of Tokyo, 503, 8th Building, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan;

    Biomedical Engineering (Ushida and Furukawa), Laboratory, Department of Mechanical Engineering, Graduate School of Engineering, University of Tokyo, 503, 8th Building, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan;

    Biomedical Engineering (Ushida and Furukawa), Laboratory, Department of Mechanical Engineering, Graduate School of Engineering, University of Tokyo, 503, 8th Building, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan;

    Advance Co., Saitama, Japan;

    Advance Co., Saitama, Japan;

    Biomedical Engineering (Ushida and Furukawa), Laboratory, Department of Mechanical Engineering, Graduate School of Engineering, University of Tokyo, 503, 8th Building, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan;

    Advance Co., Saitama, Japan;

    Biomedical Engineering (Ushida and Furukawa), Laboratory, Department of Mechanical Engineering, Graduate School of Engineering, University of Tokyo, 503, 8th Building, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 工程材料学;
  • 关键词

    bone tissue engineering; sheet; beads; bone marrow cells;

    机译：骨组织工程;薄片;珠子;骨髓细胞;

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