Effect of citric acid addition on disaggregation of crystalline hydroxyapatite nanoparticles under calcium-rich conditions

摘要

The effect of citric acid (CA) addition on the disaggregation of crystalline hydroxyapatite (HAp) nanoparticles under calcium-rich conditions was investigated in this study. HAp nanoparticles were prepared by a wet chemical precipitation process under calcium-rich conditions, which included an excess amount of calcium ions compared with the stoichiometric Ca/P molar ratio of HAp, with added CA. The formation of calcium citrate under calcium-rich conditions was highly effective for inhibiting the aggregation of nanosize HAp primary particles, and thus highly crystalline and disaggregated HAp nanoparticles were obtained. (C) 2015 Elsevier B.V. All rights reserved.