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New addition salt of azithromycin and citric acid useful for the treatment of infection caused by bacteria or protozoans contains specific molar ratio of azithromycin and citric acid
New addition salt of azithromycin and citric acid useful for the treatment of infection caused by bacteria or protozoans contains specific molar ratio of azithromycin and citric acid
Addition salt of azithromycin and citric acid is new. The molar ratio of the azithromycin and the citric acid is such that it provides a pH of 4 - 8 in a 10% aqueous solution. Independent claims are included for the following: (1) preparing an addition salt of azithromycin and citric acid involving (a) dissolving azithromycin in solvent(s); (b) adding citric acid; and (c) isolating the product obtained; and (2) preparing solutions of at least one addition salt of azithromycin and citric acid in water or water-alcohol mixtures of up to 65%, involving dissolving azithromycin and citric acid by stirring at ambient temperature; and filtering the solution obtained. ACTIVITY : Antibacterial; Protozoacide. MECHANISM OF ACTION : None given.
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