Selective Inhibitors of Bacterial Phosphopantothenoylcysteine Synthetase

摘要

Phosphopantetheine is a fundamental feature in many biological acyl transfer reactions. The molecule is found embedded within coenzyme A (CoA), as well as on a post-translationally modified, conserved serine of acyl carrier protein (ACP). Both CoA and ACP play essential roles as acyl group donor substrates in several reactions associated with intermediary metabolism and cell membrane assembly in living organisms. Comparative genomics, using phylogenetic profiling, has concluded that the synthesis of phos-phopantetheine-containing molecules from common metabolic precursors is fundamentally conserved across all domains of life.