Membrane Lipids Influence Protein Complex Assembly-Disassembly

摘要

The chemistry of life processes is governed at the molecular level. For example, membrane-directed self-assembly of a supramolecular ring complex is required for the establishment of continuity between opposing membrane compartments in cells. Neurotransmission and the secretion of hormones or digestive enzymes all involve fusion of cellular membranes. At the nerve terminal, fusion involves the conserved target membrane proteins SNAP-25 and syntaxin 1A, termed t-SNAREs, and the synaptic vesicle-associated membrane protein VAMP2, termed v-SNARE.