Flow Induced Dispersion Analysis Quantifies Noncovalent Interactions in Nanoliter Samples

摘要

Noncovalent interactions play a key role in many biochemical processes related to for example drug targets or protein-protein interactions. In combinatorial chemistry and in drug development a large number of noncovalent interactions need to be addressed in a limited time frame. Furthermore, often a very small sample amount is available for study which prevents a comprehensive characterization using existing methods. Finally, it is complicated from a technological point of view to integrate standard procedures for addressing noncovalent interactions with binding target isolation and/or synthesis of chemical entities.