Sequential Rhodium-Catalyzed Stereo- and Regioselective Addition of Organoboron Derivatives to the Alkyl 4-Hydroxy-2-Alkynoates/Lactonizaction Reaction

摘要

The sequential rhodium-catalyzed addition/lactonization reaction of organoboron derivatives to alkyl 4-hydroxy-2-alkynoates would constitute a novel methodology for the synthesis of 4-aryl/heteroaryl/ vinyl-2(5)-furanones with an excellent control of the regio- and chemoselectivity. The role played by rhodium precatalyst, ligands, reaction medium, and the feature of organoboron derivatives has been explored.