Purification of EPA Ethyl Ester from Fish Oil with a Supercritical CO_2 Temperature Gradient Rectification Column

摘要

Ethyl icosapentaenoic acid (EPA-Et) was concentrated from fish oil with Super- critical CO_2 using a rectification column in 9.7 mm internal diameter and 1100 mm effective height. To improve supercritical fluid-liquid contact, "Tawashi" rotor was placed in the extrac- tion cell and the column was packed with Dixon Packing. For greater separation capacity, the column temperature gradient from bottom to top was 35 to 80℃.