Thrombophilia can be defined as predis- position to thrombosis. Abnormalities in haemostasis that are associated with clinical thromobphilia include heritable defects, such as mutations in the genes encoding the natural anticoagulants anti- thrombin, protein C, and protein S, or clotting factors prothrombin and factor V, and acquired defects, such as antiphos- pholipids. Women with thrombophilic de- fects have been shown to be at increased risk, not only of pregnancy associated thromboembolism, but also of other vas- cular complications of pregnancy, include- ing pre-eclampisa and featl loss.
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