In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir

Jennifer L. McKimm-Breschkin12* Christina Rootes2 Peter G. Mohr2 Susan Barrett12 and Victor A. Streltsov1

首页> 外文期刊>Journal of Antimicrobial Chemotherapy >In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir

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In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir

机译：大流行H1N1 / 09病毒的体外传代选择了具有神经氨酸酶突变的病毒，这些病毒赋予了对oseltamivir和peramivir的高水平耐药性，但对zanamivir没有

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《Journal of Antimicrobial Chemotherapy》 |2012年第8期|p.1874-1883|共10页
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Jennifer L. McKimm-Breschkin12* Christina Rootes2 Peter G. Mohr2 Susan Barrett12 and Victor A. Streltsov1;
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1CSIRO Materials Science and Engineering, Parkville, Australia, 3052 2CSIRO Australian Animal Health Laboratory, Private Bag 24, Geelong, Australia, 3220;

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1. In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir [J] . Mckimm-BreschkinJ.L., RootesC., MohrP.G., The Journal of Antimicrobial Chemotherapy . 2012,第8期

机译：大流行H1N1 / 09病毒的体外传代选择了具有神经氨酸酶突变的病毒，这些病毒赋予了对oseltamivir和peramivir的高水平抗药性，但对zanamivir没有抗药性
2. Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses [J] . Jeff Butler, Kathryn A. Hooper, Stephen Petrie, PLoS Pathogens . 2014,第4期

机译：估计最近耐奥司他韦的A（H1N1）pdm09流感病毒中允许的神经氨酸酶突变所带来的健身优势
3. Effect of the neuraminidase mutation H274Y conferring resistance to oseltamivir on the replicative capacity and virulence of old and recent human influenza A(H1N1) viruses. [J] . Baz M, Abed Y, Simon The Journal of Infectious Diseases . 2010,第5期

机译：赋予对奥司他韦抗性的神经氨酸酶突变H274Y对旧的和最近的人类A型流感病毒（H1N1）的复制能力和毒力的影响。
4. Simulated Docking of Oseltamivir with the 1918 Pandemic Strain Influenza A/H1N1 "Zanamivir-Conformed" Neuraminidase Active Site [C] . Jack K. Homer International Conference on Genetic and Evolutionary Methods . 2011

机译：用1918大流行菌甲型流感A / H1N1“Zanamivir-符合”神经氨酸活性位点模拟对接
5. Spatial and temporal patterns of genetic variation of H1N1 influenza viruses in China in the 2009 pandemic. [D] . Shang, Yiqing. 2014

机译：2009年中国大流行H1N1流感病毒遗传变异的时空格局。
6. I223R Mutation in Influenza A(H1N1)pdm09 Neuraminidase Confers Reduced Susceptibility to Oseltamivir and Zanamivir and Enhanced Resistance with H275Y [O] . Jérome LeGoff, Dominique Rousset, Georges Abou-Jaoudé, -1

机译：I223R突变流感a（H1N1）pdm09神经氨酸酶赋予敏感性降低到奥司他韦和扎那米韦和与H275Y抗性提高
7. In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir [O] . J. L. McKimm-Breschkin, C. Rootes, P. G. Mohr, 2012

机译：大流行H1N1 / 09病毒的体外传递用于赋予Oseltamivir和Peramivir的高水位抗性的神经氨酸酶突变的病毒，但不是Zanamivir

In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir

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