A convenient preparation of several N-linked glycoamino acid building blocks for efficient solid-phase synthesis of glycopeptides

摘要

A convenient, high yielding route for the preparation of several Boc- and Fmoc-protected N-linkednglycopeptide monomers is presented. These building blocks can be used for the solid-phase synthesisnof glycopeptides or glycopeptidomimetics, which is exemplified by the preparation of an N-linkedndodecaglycopeptide Ac–(GlyProAsn[Gal])4–NH2, a potential collagen mimic.