Pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine, and effects of CYP3A5 and MDR1 polymorphisms in patients with urogenital cancers

Mari Jiko; Ikuko Yano; Eriko Sato; Kazushige Takahashi; Hideyuki Motohashi; Satohiro Masuda; Masahiro Okuda; Noriyuki Ito; Eijiro Nakamura; Takehiko Segawa; Toshiyuki Kamoto; Osamu Ogawa; Ken-ichi Inui

首页> 外文期刊>International Journal of Clinical Oncology >Pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine, and effects of CYP3A5 and MDR1 polymorphisms in patients with urogenital cancers

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Pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine, and effects of CYP3A5 and MDR1 polymorphisms in patients with urogenital cancers

机译：紫杉醇与卡铂或吉西他滨的药代动力学和药效学，以及CYP3A5和MDR1基因多态性在泌尿生殖系统癌症患者中的作用

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摘要

We investigated the pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine in patients with urogenital cancer to clarify the significance of monitoring of the serum concentration of paclitaxel.

机译：我们调查了紫杉醇联合卡铂或吉西他滨在泌尿生殖系统癌症患者中的药代动力学和药效学，以阐明监测紫杉醇血清浓度的重要性。

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来源
《International Journal of Clinical Oncology》 |2007年第4期|284-290|共7页
作者
Mari Jiko; Ikuko Yano; Eriko Sato; Kazushige Takahashi; Hideyuki Motohashi; Satohiro Masuda; Masahiro Okuda; Noriyuki Ito; Eijiro Nakamura; Takehiko Segawa; Toshiyuki Kamoto; Osamu Ogawa; Ken-ichi Inui;
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作者单位

Department of Pharmacy Kyoto University Hospital Faculty of Medicine Kyoto University Sakyo-ku Kyoto 606-8507 Japan;

Department of Pharmacy Kyoto University Hospital Faculty of Medicine Kyoto University Sakyo-ku Kyoto 606-8507 Japan;

Department of Pharmacy Kyoto University Hospital Faculty of Medicine Kyoto University Sakyo-ku Kyoto 606-8507 Japan;

Department of Pharmacy Kyoto University Hospital Faculty of Medicine Kyoto University Sakyo-ku Kyoto 606-8507 Japan;

Department of Pharmacy Kyoto University Hospital Faculty of Medicine Kyoto University Sakyo-ku Kyoto 606-8507 Japan;

Department of Pharmacy Kyoto University Hospital Faculty of Medicine Kyoto University Sakyo-ku Kyoto 606-8507 Japan;

Department of Pharmacy Kyoto University Hospital Faculty of Medicine Kyoto University Sakyo-ku Kyoto 606-8507 Japan;

Department of Urology Graduate School of Medicine Kyoto University Kyoto Japan;

Department of Urology Graduate School of Medicine Kyoto University Kyoto Japan;

Department of Urology Graduate School of Medicine Kyoto University Kyoto Japan;

Department of Urology Graduate School of Medicine Kyoto University Kyoto Japan;

Department of Urology Graduate School of Medicine Kyoto University Kyoto Japan;

Department of Pharmacy Kyoto University Hospital Faculty of Medicine Kyoto University Sakyo-ku Kyoto 606-8507 Japan;

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原文格式 PDF
正文语种 eng
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关键词
Paclitaxel; Pharmacokinetics; Pharmacodynamics; Carboplatin; Gemcitabine;

机译：紫杉醇;药代动力学;药效学;卡铂;吉西他滨;

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专利

1. Pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine, and effects of CYP3A5 and MDR1 polymorphisms in patients with urogenital cancers. [J] . Jiko M, Yano I, Sato E, International journal of clinical oncology . 2007,第4期

机译：紫杉醇与卡铂或吉西他滨的药代动力学和药效学，以及CYP3A5和MDR1多态性在泌尿生殖系统癌症患者中的作用。
2. Effects of sequential paclitaxel-carboplatin followed by gemcitabine-based chemotherapy compared with paclitaxel-carboplatin therapy administered to patients with advanced epithelial ovarian cancer A retrospective, STROBE-compliant study [J] . Wang Fei, Du Xuelian, Li Xiaoxia, Medicine. . 2016,第51期

机译：晚期紫癜性卵巢癌患者序贯紫杉醇卡铂联合吉西他滨化疗与紫杉醇卡铂治疗的疗效比较
3. Effects of sequential paclitaxel–carboplatin followed by gemcitabine-based chemotherapy compared with paclitaxel-carboplatin therapy administered to patients with advanced epithelial ovarian cancer: A retrospective, STROBE-compliant study [J] . Wang Fei, Du Xuelian, Li Xiaoxia, Medicine. . 2016,第51期

机译：顺序紫杉醇 - 卡铂的作用随着紫霉素的化疗与先进上皮性卵巢癌患者患者的紫杉醇 - 卡铂治疗相比：兼容频闪的研究
4. Association of Multi-Drug Resistance-1 (MDR1) Gene Polymorphism with Leukocytopenia in Breast Cancer Patients treated with Chemotherapy [C] . Siti Syarifah, Tri Widyawati, Kamal B. Siregar, Public Health International Conference . 2017

机译：化疗治疗乳腺癌患者白细胞凋亡的多药抗性-1（MDR1）基因多态性的关联
5. Pharmacokinetic and Pharmacodynamic Analysis of Gemcitabine and Birinapant Combinations in Pancreatic Cancer. [D] . Zhu, Xu. 2017

机译：吉西他滨和Birinapant组合在胰腺癌中的药代动力学和药效学分析。
6. Effects of sequential paclitaxel–carboplatin followed by gemcitabine-based chemotherapy compared with paclitaxel-carboplatin therapy administered to patients with advanced epithelial ovarian cancer [O] . Fei Wang, Xuelian Du, Xiaoxia Li, -1

机译：晚期紫癜性卵巢癌患者序贯紫杉醇卡铂联合吉西他滨化疗与紫杉醇卡铂治疗的比较
7. Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients:A study by the European Organization for Research and Treatment of Cancer-Pharmacology and Molecular Mechanisms Group and New Drug Development Group [O] . Joerger, Markus, Huitema, Alwin D. R., Richel, Dick J., 2007

机译：紫杉醇和卡铂在卵巢癌患者中的群体药代动力学和药效学：欧洲癌症研究和治疗组织-药理与分子机制研究组和新药开发组的研究

Pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine, and effects of CYP3A5 and MDR1 polymorphisms in patients with urogenital cancers

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