Effects of Weight Loss and Exercise on the Distribution of Lead and Essential Trace Elements in Rats with Prior Lead Exposure

摘要

We studied the effects of weight loss and non-weight-bearing exercise (swimming) on blood and organ lead and essential metal concentrations in rats with prior lead exposure. Nine-week-old female Sprague-Dawley rats (n = 37) received lead acetate in their drinking water for 2 weeks, fol- lowed by a 4-day latency period without lead exposure. Rats were then randomly assigned to one of six treatment groups: weight maintenance with ad libitum feeding, moderate weight loss with 20 /100 food restriction, and substantial weight loss with 40 /100 food restriction, either with or with- out swimming.