Brief Genetics Report: Human Insulin Receptor Substrate-2 Gene Organization and Promoter Characterization

摘要

Insulin receptor substrate-2 (IRS-2) belongs to a fam- ily of cytoplasmic adaptor proteins, which link insulin, IGF-1, and cytokine receptor tyrosine kinases to sig- Naling pathways regulating metabolism, growth, and Differentiation (1-3). IRS-2-deficient mice display all Characteristics of type 2 diabetes, suggesting that Dysfunction of the IRS-2 gene may contribute to the Pathogenesis of human type 2 diabetes (4). Based on its Progesterone inducibility, we have recently cloned and Sequenced a full-length human IRS-2 cDNA containing An open reading frame (ORF) of 4,014 bp and 5'-and 3'- Untranslated regions (UTRs) of 516 and 2,466 bq (5).