Diguanidinocalix[4]arenes as effective and selective catalysts of the cleavage of diribonucleoside monophosphates

摘要

Calix[4]arenes derivatives 1 and 2 , featuring two guanidine units at the upper rim, catalyze the transesterification of diribonucleoside monophosphates much more effectively than that of HPNP. Rate accelerations relative to the background range from 10 ~(3) to 10 ~(4) -fold, and approach 10 ~(5) -fold with the most favorable substrate-catalyst combinations.