An advanced molecular biology course called Architecture and Dynamics of the Nucleus was offered in Spring 2018 ata private R1 university. A total of 15 students—2 graduate students, 11 seniors, 2 juniors, and 1 sophomore—wereenrolled and the class met twice a week (75 min per class). Learning objectives of the course were to (1) understandmultiple layers of regulation of gene expression and nuclear-cytoplasmic communications, (2) connect seeminglydistinct cellular processes and speculate how they would influence one another, (3) make critical assessments ofscientific research papers, and (4) weave engaging and logical stories with scientific information. The course comprisedsix topics and each topic had two or three lectures followed by students’ HERE presentations. The lectures not onlycovered major concepts in the field of molecular biology, but also introduced cutting-edge experimental tools. Instead ofin-class exams, students took take-home exams designed to evaluate the ability to comprehend scientific papers anddesign future experiments.
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