Can pathoanatomical pathways of degeneration in lumbar motion segments be identified by clustering MRI findings

摘要

Background Magnetic Resonance Imaging (MRI) is the gold standard for detailed visualisation of spinal pathological and degenerative processes, but the prevailing view is that such imaging findings have little or no clinical relevance for low back pain. This is because these findings appear to have little association with treatment effects in clinical populations, and mostly a weak association with the presence of pain in the general population. However, almost all research into these associations is based on the examination of individual MRI findings, despite its being very common for multiple MRI findings to coexist. Therefore, this proof-of-concept study investigated the capacity of a multivariable statistical method to identify clusters of MRI findings and for those clusters to be grouped into pathways of vertebral degeneration. Methods This study is a secondary analysis of data from 631 patients, from an outpatient spine clinic, who had been screened for inclusion in a randomised controlled trial. The available data created a total sample pool of 3,155 vertebral motion segments. The mean age of the cohort was 42?years (SD 10.8, range 18–73) and 54% were women. MRI images were quantitatively coded by an experienced musculoskeletal research radiologist using a detailed and standardised research MRI evaluation protocol that has demonstrated high reproducibility. Comprehensive MRI findings descriptive of the disco-vertebral component of lumbar vertebrae were clustered using Latent Class Analysis. Two pairs of researchers, each containing an experienced MRI researcher, then independently categorised the clusters into hypothetical pathoanatomic pathways based on the known histological changes of discovertebral degeneration. Results Twelve clusters of MRI findings were identified, described and grouped into five different hypothetical pathways of degeneration that appear to have face validity. Conclusions This study has shown that Latent Class Analysis can be used to identify clusters of MRI findings from people with LBP and that those clusters can be grouped into degenerative pathways that are biologically plausible. If these clusters of MRI findings are reproducible in other datasets of similar patients, they may form a stable platform to investigate the relationship between degenerative pathways and clinically important characteristics such as pain and activity limitation.