Evaluation of Genotoxicity of Ethyl Methanesulfonate (EMS) Using Human Lymphocytes

摘要

ABSTRACT Among the class of ethylating agents known, ethyl methanesulfonate (EMS) is a potential carcinogen and a mutagen. The objective of the present study is to determine the genotoxic potential of ethyl methanesulfonate in human peripheral blood lymphocytes using the gold-standard chromosomal aberration assay. Peripheral blood, collected from a healthy donor was exposed to various concentrations (0.5M, 0.05M and 0.005M) of EMS for 24 hours and 48 hours. Following exposure, the analysis reve.