Increased miR‐222 in H. pylori‐associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK

摘要

LittleisknownaboutthepotentialroleofmicroRNAs(miRNAs)inthecarcinogenesisofgastriccancerinducedbyHelicobacterpylori(H.pylori).Here,weshowedthatmicroRNA‐222(miR‐222)wasup‐regulatedinH.pylori‐infectedgastricmucosaandgastriccancer.EctopicexpressionofmiR‐222promotedcellproliferationandcolonyformationinvitro.Mechanistically,weidentifiedRECKasanoveltargetofmiR‐222,andalsoconfirmedtheirrelationshipbytheinversecorrelationofmRNAexpressionexvivo.Furthermore,wefoundthatRNAinterferencesilencingofRECKcanmimictheoncogeniceffectsofmiR‐222.Collectively,H.pylorimayfunctionasaninitiatorintheprocessofcarcinogenesisbyup‐regulatingmiR‐222,whichfurtherparticipatesintheprogressionofcancerbypromotingproliferationandinhibitingRECK...