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Determination of Picogram Levels of Diacerein in a Pharmaceutical Formulation by Flow-Injection Chemiluminescence

机译:流动注射化学发光法测定药物制剂中双醋瑞因的皮克水平

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A simple, sensitive and inexpensive method for determination of diacerein by flow-injection chemiluminescence was proposed, based on the quenching effect of diacerein on the luminol-protein (bovine serum albumin, BSA) reaction. It was found that the decrement of CL intensity was linearly proportional to the logarithm of diacerein concentration ranging from 5.0 to 7.0×103 pg·mL-1 (r = 0.9968), with the limit of detection (LOD) of 1.0 pg·mL-1 (3σ). The proposed procedure was successfully applied to the determination of diacerein in pharmaceutical formulation, human saliva, and serum samples without interference from its potential impurities, with the recoveries ranging from 96.4% to 104.0% and the relative standard deviations (RSDs) less than 4.0% (n=6).
机译:提出了一种基于双醋瑞因对鲁米诺蛋白(牛血清白蛋白,牛血清白蛋白)反应的猝灭作用的简单,灵敏和廉价的方法,用于通过流动注射化学发光法测定双醋瑞因。发现CL强度的降低与双醋瑞因浓度的对数线性成正比,范围从5.0到7.0×103 pg·mL-1(r = 0.9968),检出限(LOD)为1.0 pg·mL- 1(3σ)。该方法成功用于药物制剂,人唾液和血清样品中双醋瑞因的测定,不受其潜在杂质的干扰,回收率在96.4%至104.0%之间,相对标准偏差(RSD)小于4.0% (n = 6)。

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