Distribution and Genetic Diversity of Plasmodium falciparum Erythrocyte Binding Antigen 175 and Clinical Outcome of Malaria in the Kassena-Nankana District

摘要

The Erythrocyte Binding Antigen 175 (EBA 175) is a 175?kDalton Plasmodium falciparum antigen which plays a major role in erythrocyte recognition by the parasite. It also induces antibodies which inhibit merozoite invasion. EBA 175 has been sequenced from FCR-3 and CAMP strains of Plasmodium falciparum. The sequences were identical in most parts of the gene, differences were apparent in the 423bp segment in the FCR-3 strain, the F-genotype, and the 342bp segment, the C-genotype. Parasite strains possess either one or the other segment and never both.