Method for preparing Plasmodium falciparum strain HRPII antigen and a malaria vaccine containing this antigen, a DNA and RNA sequence encoding the HRPII antigen, and a vector and bacterial cell containing this DNA

摘要

A gene which codes for a histidine/alanine-rich protein has been isolated by screening two different Plasmodium falciparum cDNA gene banks with antiserum against a 41 kD protein and by cross-hybridisation with the insert DNA of a clone obtained therewith. The protein protects aotus monkeys from infection with P. falciparum and is thus a suitable component of a malaria vaccine.