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Vaccine comprises chimeric malaria proteins derived from Plasmodium falciparum genetically coupled to Plasmodium falcinarum Merozoite surface protein 3
Vaccine comprises chimeric malaria proteins derived from Plasmodium falciparum genetically coupled to Plasmodium falcinarum Merozoite surface protein 3
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机译:疫苗包含源自恶性疟原虫的嵌合疟疾蛋白,该蛋白通过遗传与恶性疟原虫裂殖子表面蛋白3遗传偶联
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摘要
The vaccine comprises chimeric malaria proteins derived from Plasmodium falciparum genetically coupled to Plasmodium falcinarum Merozoite surface protein 3. The vaccine is produced in Lactococcus lactis as a secreted recombinant hybrid protein. Experiments show that the Glutamate-rich protein part of the hybrid increases the overall antibody response. - Immunizations with the hybrid protein consistently generates a stronger antibody response against the individual Glutamate rich protein and Merozoite surface protein 3 domains than a mixture of the two recombinant molecules injected at one site or the individual recombinant molecules injected simultaneously at two different sites.
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