Generation of Monoclonal Antibodies Against Recombinant Capsular Antigen of Burkholderia mallei and Its Potential Application in Glanders Disease Diagnosis

摘要

Glanders is primarily a disease of solipeds, most mammals have a certain degree of susceptibility and infection has been reported in goats, sheep, camels, cats, dogs and various other carnivores, human cases of glanders have rarely been reported. Glanders was eradicated in many countries through the use of the mallein test and also with the application of countermeasures like intensive blood testing, rigorous culling of positive animals and strict trading restrictions but sporadic cases still occur in Asia, Africa, the Middle East, and South America.