Are Cystatin C and β2-Microglobulin Better Markers than Serum Creatinine for Prediction of a Normal Glomerular Filtration Rate in Pediatric Subjects?

摘要

Serum creatinine is the marker most widely used to predict glomerular filtration rate (GFR). In childhood, there is age and muscle mass dependency of serum creatinine, and assessing a normal GFR accurately even with the use of body length/creatinine ratios remains difficult (1)(2). Recently, cystatin C (Cys-C), a 13-kDa protein, was found to correlate closely with GFR in adults (3)(4)(5). β2-Microglobulin (β2-MG) serum concentrations also correlate with GFR, and have been shown to be age independent in infants (6). Here, we report reference limits of Cys-C and β2-MG in children between ages 0.8 and 18 years and demonstrate age independency of these parameters as an essential advantage compared with the conventionally used serum creatinine values.We studied serum Cys-C and β2-MG in 216 urological pediatric patients (age range 0.8 to 18 years, mean 11.0 …