Biomarkers for Precisely Predicting the Glomerular Filtration Rate and for Indicating Pathophysiologic Factors of an Impaired Glomerular Filtration Rate

摘要

An in vitro method for calculating a glomerular filtration rate of an individual or an indicator of a pathophysiologic factor of an impaired glomerular filtration rate is provided. The method may include the following steps: providing a blood sample from an individual; determining the concentration of at least three substances chosen from alanine, choline, creatine, creatinine, dimethyl sulfone, dimethylamine, glucose, glycerol, isoleucine, leucine, myo-inositol, N,N-dimethylglycine, and valine in the blood sample by analyzing the blood sample with a suited measuring technique; and calculating a predicted glomerular filtration rate or an indicator of a pathophysiologic factor of an impaired glomerular filtration rate from the determined concentrations of the substances.