Objective To investigate clinical evaluation on the diagnosis of early renal damage in hyperuricemia detection of serum cystatin C, serum creatinine, β2-microglobulin in urine as an effective scientific basis on the early diagnosis of renal damage by hyperuricemia. Methods 74 patients consistent with primary hyperuricemia criteria for the diagnosis were selected in the hospital from September 2009 to January 2012 as the observation group. 74 comparable and health personnel were selected as the control group. Serum cystatin C, serum creatinine andc-microglobulin in urine of two groups were analyzed and compared. Results Serum cystatin C of (1.1 ±0.3) mg/L, serum creatinine of (98.6± 14.5) (Jimol/L, p2-mi-croglobulin in urine of (0.2±0.1) mg/L in the observation group were significantly higher than that in the control group with serum cystatin C of (0.6+0.2) mg/L, serum creatinine (84.1 ±12.9) (μmol/L, β2~microglobulin in urine of (0.1 ±0) mg/L. The difference had a statistical significance (P < 0.05 or P < 0.01). Serum cystatin C, serum creatinine, β2-microglobulin in urine in the observation group had certain correlation between each index. Conclusion The detection of serum cystatin C, serum creatinine and β2~microglobulin in urine can be different degree of hyperuricemia in patients with glomerular filtration function damage condition. Three kinds of detection methods can be used in the diagnosis of early renal damage of sensitive index. The detection of serum cystatin C, serum creatinine and β2~microglobulin in urine as the early diagnosis of hyperuricemic renal impairment is safe and effective detection method, which is worthy of clinical use.%目的 探讨血清胱抑素C、血清肌酐和尿β2-微球蛋白检测对高尿酸血症肾损害早期诊断的临床价值,为高尿酸血症肾损害的早期诊断提供有效的科学依据.方法 选取解放军总医院2009年9月～2012年1月收治的符合原发性高尿酸血症诊断标准的患者74例作为观察组,同时选取具有可比性的健康人员74例作为对照组,检测两组人员的血清胱抑素C、血清肌酐和尿β2-微球蛋白,并进行比较分析.结果 观察组血清胱抑素C[(1.1±0.3)mg/L]、血清肌酐[(98.6±14.5)μmol/L]、尿β2-微球蛋白[(0.2±0.1)mg/L]均明显高于对照组血清胱抑素C[(0.6±0.2)mg/L]、血清肌酐[(84.1±12.9)μmol/L]、尿β2-微球蛋白[(0.1±0.0)mg/L],差异有统计学意义(P ＜ 0.05或P ＜ 0.01).观察组血清胱抑素C、血清肌酐、尿β2-微球蛋白各指标间具有一定的相关性.结论 血清胱抑素C、血清肌酐和尿β2-微球蛋白检测均能不同程度反映高尿酸血症患者肾小球滤过功能的损害状况,三种检测方法 均可作为高尿酸血症肾损害早期诊断的敏感指标.血清胱抑素C、血清肌酐和尿β2-微球蛋白检测用于早期诊断高尿酸血症肾损害是安全有效的检测方法,值得临床推广使用.
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