Protective Effect of Alpina nigra Leaves Extract in Mouse Liver Injury Induced by Carbon Tetrachloride

摘要

The present study was aimed to evaluate the hepatoprotective activity of methanol extract against carbon tetrachloride (CCl 4 ) induced hepatic damage in rats. CCl 4 caused liver damage in rats manifested by significant rise in serum enzyme levels. To examine the effect of the extract male albino rats were used and extract was administered orally at a dose of 300 mg/kg once daily. The results obtained showed that there were reductions in the activities of serum SGOT, SGPT, ALP, total protein, total bilirubin from 97.67±1.78, 275.67±2.86, 934 ± 1.41, 1.13±0.227 and 7.50±0.707 in animals treated with toxic doses of CCl 4 to 78.33±1.08, 53±1.41, 870±0.707, 0.67±0.04 and 6.47±0.356 in animal treated with extract before CCl 4 intoxication. The extract could also repair the abnormal lipid profile. From these results, it is concluded that methanol extract of Alpina nigra leaves has hepatoprotective activity in CCl 4 -induced hepatic damage in rats.