Antidiabetic Activity and Safety Used of Nutrasucre, a Food Complement, in Alloxan Induced Diabetic Rats

摘要

Background and Objective: Type 2 diabetes is one of the major public health problem arround the world and particularly in Cote d'Ivoire. The relation ship between sugar consumption and type 2 diabetes treatment remained critical to be discovered. Nutrasucre, a food complement containing brown sugar and extracts of medicinal plant s used for the treatment of type 2 diabetes in Cote d?Ivoire. This study aimed nutrasucre?s aptitude to reduce glycemia and its safety used may provide a likely profit by supporting sugar consumption in type 2 diabetes treatment. Materials and Methods: Thirty five diabetics rats received nutrasucre solution at 1.43, 2.86 and 5.71 g kg^?1 b.w., respectively. Blood withdrawals were performed at the end of treatment. Biochemical parameters were assessed: Glycemia, urea, creatinine, transaminases (ALAT, ASAT), triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol. Acute and sub acute toxicity were carried out using OECD Guidelines 423 and 407, respectively. Kidneys, heart and liver tissues were collected and subjected to microscopical analysis. One-way analysis of variance (ANOVA 1) and multiple comparisons of Tukey-Kramer post-hoc test were being used. Results: Nutrasucre possessed antihyperglycemic effect comparable to glibenclamide, a reference antihyperglycemic drug and increased triglyceride, total cholesterol, HDL and LDH cholesterols levels. This increase was significant for triglycerides (p50 value of nutrasucre was higher than 5000 mg kg^?1 b.w. and was classified as non toxic in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS). No signs of sub acute toxicity were recorded during the 28 observation days. Finally, the repeated administration of nutrasucre did not affect various vital organs. Conclusion: It is concluded that nutrasucre was antihyperglycemic, nontoxic and does not affect vital organs such as kidneys, liver and heart. It reduces serum ASAT, ALAT and total, LDH and HDL levels and contains hypolipidic substances. It can be advised as antidiabetic food complement.