Platelet Counts in Children With Henoch–Schonlein Purpura—Relationship to Renal Involvement

摘要

Background The aim of this study is to identify the clinical and laboratory risk factors for renal involvement and to determine the relationship between platelet counts and renal involvement in (Henoch–Sch?nlein purpura) HSP patients. Methods We reviewed the medical records of 107 children with HSP according to Eular/Press diagnostic criteria. Clinical and laboratory parameters for renal involvement were evaluated and compared to no renal involvement. Results A retrospective study consisted of 107 children, 61 boys (57%), and 46 girls (43%). Twenty-eight of the 107 patients (26.1%) had renal involvement. The mean platelet count was significantly higher in patients with renal involvement when compared to patients without renal involvement ( P = 0.001). The multivariate logistic regression analysis identified that age ( P = 0.022), sex ( P = 0.037), gastrointestinal involvement ( P =?0.019), and platelet count ( P = 0.019) were significantly associated with the renal involvement of HSP. The platelet count was predictive of renal involvement, which had odds ratio of 1.0, and achieved area under the curve of 0.66 for predicting the renal involvement within the acute stage of HSP ( P =?0.009). Conclusion Our study indicated that age, sex, gastrointestinal involvement, and platelet count were significant risk factors of renal involvement of HSP.